Publications

Cell-permeable miniature proteins via -helical arginine display. B. Smith, D.S. Daniels, A. Coplin, G. Jordan, & L. McGregor, & A. Schepartz, J. Am. Chem. Soc. 2008, 130, 2948-2949.

Toward ß-amino acid proteins: design, synthesis, and characterization of a fifteen kilodalton ß-peptide tetramer. E.J. Petersson & A. Schepartz, J. Am. Chem. Soc. 2008, 130, 821-823.

Intrinsically cell-permeable miniature proteins based on a minimal cationic PPll motif. D.S. Daniels & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 14578-14579. Check out the Commentary in C&E News!

Surveying polypeptide and protein domain conformation and association with FIAsH and ReAsH. N.W. Luedtke, R.J. Dexter, D.B. Fried, & A. Schepartz, Nat. Chem. Biol. 2007, 3, 779-784. Read the highlight in Science! Read the highlight in Nature Methods!

Biophysical and structural characterizaion of a robust octameric ß-peptide bundle. J.L. Goodman, E.J. Petersson, D.S. Daniels, J.X. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 14746-14751.

Sophistication of foldamer form and function in vitro and in vivo. A.D. Bautista, C.J. Craig, E.A. Harker, & A. Schepartz, Curr. Op. Chem. Biol. 2007, 11, 685-692.

Miniature protein ligands for EVH1 domains: Interplay between affinity, specificity, and cell motility. J.H. Holtzman, K. Woronowicz, D. Golemi-Kotra, & A. Schepartz, Biochemistry 2007, 46, 13541-13553. Chosen as Hot Article!

Engineering a monomeric miniature protein. A.M. Hodges & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 11024-11025 .

Biophysical characterization of a ß-peptide bundle: Comparison to natural proteins. E.J. Petersson, C.J. Craig, D.S. Daniels, J.X. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 5344-5345.

High resolution structure of a ß-peptide bundle. D.S. Daniels, E.J. Petersson, J.X. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 1532-1533.

Encodable activators of Src family kinases. C.D. Zellefrow, J.S. Griffiths, S. Saha, A.M. Hodges, J.L. Goodman, J. Paulk, J.A. Kritzer, & A. Schepartz, J. Am. Chem. Soc. 2006, 128, 16506-16507.

Toward ß-amino acid proteins: A cooperatively folded ß-peptide quaternary structure. J.X. Qiu, E.J. Petersson, E.E. Matthews, & A. Schepartz, J. Am. Chem. Soc. 2006, 128, 11338-11339.

Relationship between salt-bridge identity and 14-helix stability of ß³-peptides in aqueous buffer. D.A. Guarracino, H.R. Chiang, T.N. Banks, J.D. Lear, M.E. Hodsdon, & A. Schepartz, Org Lett. 2006, 8, 807-810.

Miniature protein inhibitors of the p53-hDM2 interaction. J.A. Kritzer, R. Zutshi, M. Cheah, F.A. Ran, R. Webman, T.M. Wongjirad, & A. Schepartz, ChemBioChem. 2006, 7, 29-31.

A rapid library screen for tailoring ß-peptide structure and function. J.A. Kritzer, N.W. Luedtke, E.A. Harker, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 14584-14585.

Lanthanide-mediated phosphoester hydrolysis and phosphate elimination from phosphopeptides. N.W. Luedtke & A. Schepartz, Chem. Comm. 2005, 43, 5426-5428.

Inhibiting HIV fusion with a ß-Peptide foldamer. O.M. Stephens, S. Kim, B.D. Welch, M.E. Hodsdon, M.S. Kay, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 13126-13127.

Relationship between side chain structure and 14-helix stability of ß³-peptides in water. J.A. Kritzer, J. Tirado-Rives, S.A. Hart, J.D. Lear, W.L. Jorgensen, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 167-178.

Paralog-selective ligands for Bcl-2 proteins. A.C. Gemperli, S.E. Rutledge, A. Maranda & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 1596-1597.

Binding mode and transcriptional activation potential of high affinity ligands for the CBP KIX domain. H.M. Volkman, S.E. Rutledge, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 4649-4658.

ß-peptides as inhibitors of protein-protein interactions. J.A. Kritzer, O.M. Stephens, D.A. Guarracino, S.K. Reznik, & A. Schepartz, Bio. Med. Chem. 2005, 13, 11-16. Awarded "Bioorganic Medicinal Chemistry Most Cited Paper 2003-2006"!

Solution structure of a ß-peptide ligand for hDM2. J.A. Kritzer, M.E. Hodsdon & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 4118-4119.

Relationship between folding and function in a sequence-specific miniature DNA-binding protein. L. Yang & A. Schepartz, Biochemistry 2005, 44, 7469-7478.

Increasing the kinase specificity of K252a by protein surface recognition. T.L. Schneider, R.S. Mathew, K.P. Rice, K. Tamaki, J.L. Wood & A. Schepartz, Org. Lett. 2005, 7, 1695-1698.

Helical ß-peptide inhibitors of the p53-hDM2 interaction. J.A. Kritzer, J.D. Lear, M.E. Hodsdon & A. Schepartz, J. Am. Chem. Soc. 2004, 126, 9468-9469.

High affinity, paralog-specific recognition of the Mena EVH1 domain by a miniature protein. D. Golemi-Kotra, R. Mahaffy, M.J. Footer, J.H. Holtzman, T.D. Pollard, J.A. Theriot & A. Schepartz, J. Am. Chem. Soc. 2004, 126, 4-5.

Molecular recognition of protein surfaces: High affinity ligands for the CBP KIX domain. S.E. Rutledge, H.M. Volkman & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 14336.

Helix macrodipole control of ß³-peptide 14-helix stability in water. S.A. Hart, A.B.F. Bahadoor, E.E. Matthews, X.J. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 4022.

Miniature Homeodomains: High specificity without an N-terminal arm. J.K. Montclare & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 3416.

A View to a Kill: Ligands for Bcl-2 family proteins. S.E. Rutledge, J.W. Chin & A. Schepartz, Curr. Op. Chem. Biol. 2002, 6, 479-485.

Gal4-VP16 and Gal4-AH increase the orientational and axial specificity of TATA box recognition by TBP. A.R. Kays & A. Schepartz, Biochemistry 2002, 41, 3147-3155.

Electrostatic control of half-site spacing preferences by the cyclic AMP response element binding protein CREB. J. K. Montclare, L. S. Sloan & A. Schepartz, Nucl. Acids Res. 2001, 29, 3311-3319.

Design and evolution of a miniature Bcl-2 binding protein. J.W. Chin & A. Schepartz, Angew. Chem. Int. Ed. Eng. 2001, 40, 3806-3809.

Effects of nucleic acids and polyanions on dimer formation and DNA binding by dimeric transcription factors. J.J. Kohler & A. Schepartz, Bioorg. Med. Chem. 2001, 9, 2435-2443.

Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display. J.W. Chin, R.M. Grotzfeld, M.A. Fabian & A. Schepartz, Bioorg. Med. Chem. Lett. 2001, 11, 1501-1505.

Hepatitis B virus protein pX enhances monomer assembly pathway of bZIP•DNA complexes. T.L. Schneider & A. Schepartz, Biochemistry 2001, 40, 2835-2843.

A Roller Coaster Ride of Thrills. A. Schepartz, Chem. Eng. News 2001, 125th Anniversary Issue.

Kinetic preference for oriented DNA binding by the yeast TATA-binding protein TBP. Y. Liu & A. Schepartz, Biochemistry 2001, 40, 6257-6266.

Kinetic studies of Fos•Jun•DNA complex formation: DNA binding prior to dimerization. J.J. Kohler & A. Schepartz, Biochemistry 2001, 40, 130-142.

Concerted evolution of structure and function in a miniature protein. J.W. Chin & A. Schepartz, J. Am. Chem. Soc. 2001, 123, 2929-2930.

Hepatitis B virus X protein activates transcription by bypassing CREB phosphorylation, not by stabilizing bZIP-DNA complexes. M.K. Pflum, D. Hall, T. L. Schneider, & A. Schepartz, Biochemistry 2001, 40, 693-703.

Virtually unidirectional binding of TBP to the AdMLP TATA box within quaternary complex with TFIIA and TFIIB. A.R. Kays & A. Schepartz, Chem. Biol. 2000, 7, 601-610.

Gene Regulation: Protein escorts to the transcription ball. J.W. Chin, J.J. Kohler, T.L. Schneider & A. Schepartz, Curr. Biol. 1999, 9, R929-R932.

DNA specificity enhanced by sequential binding of protein monomers. J.J. Kohler, S.J. Metallo, T.L. Schneider & A. Schepartz, Proc. Natl. Acad. Sci. USA 1999, 96, 11735-11739.

Highly specific DNA recognition by a designed, miniature protein. N.J. Zondlo & A. Schepartz, J. Am. Chem. Soc. 1999, 121, 6938-6939.

Polarity of transcription on Pol II and archaeal promoters: where is the "one-way sign" and how is it read? F. T. Tsai, O. Littlefield, P. F. Kosa, J. M. Cox, A. Schepartz & P.B. Sigler, Cold Spring Harb. Symp. Quant. Biol. 1998, 63, 53-61.

At the chemistry-biology interface. A. Schepartz & P.S. Kim, Curr. Op. Chem. Biol. 1998, 2, 9-10.

Preinitiation complex assembly: Potentially a bumpy path. J.M. Cox, A.R. Kays, J.F. Sanchez & A. Schepartz, Curr. Op. Chem. Biol. 1998, 2, 11-17.

Sequence determinants of the intrinsic bend in the cyclic AMP response element. L.S. Sloan & A. Schepartz, Biochemistry 1998, 37, 7113-7118.

Mechanism of DNA binding enhancement by the Hepatitis B virus protein X. C.R. Palmer, L.D. Gegnas, A. Schepartz, Biochemistry 1997, 36, 15349-15355.

Induced DNA bending by the Zn₂Cys₆ binuclear cluster protein PUT3. P. Hoffmann & A. Schepartz, Bio. Med. Chem. Lett. 1997, 7, 2049-2054.

Kinetics and mechanism of RNA binding by triplex tethered oligonucleotide probes. A.C. Moses & A. Schepartz, J. Am. Chem. Soc. 1997, 119, 11591-11597.

The role of a basic amino acid cluster in target site selection and nonspecific binding of bZIP peptides to DNA. S.J. Metallo, D.N. Paolella, & A. Schepartz, Nucl. Acids Res. 1997, 25, 2967-2972.

Bidirectional binding of the TATA box binding protein to the TATA box. J.M. Cox, M.H. Hayward, J.F. Sanchez, L.D. Gegnas, S. van der Zee, J.H. Dennis, P.B. Sigler, & A. Schepartz, Proc. Natl. Acad. Sci. 1997, 94, 13475-13480.

Electrostatic mechanism for DNA bending by bZIP proteins. D.N. Paolella, Y. Liu & A. Schepartz, Biochemistry 1997, 36, 10033-10038.

Inhibition of Rev•RRE complexation by triplex tethered oligonucleotide probes. A.C. Moses, S.W. Huang & A. Schepartz, Bioorg. Med. Chem. 1997, 5, 1123-1129.

Certain bZIP proteins bind DNA sequentially as monomers and dimerize on the DNA. S.J. Metallo & A. Schepartz, Nat. Str. Biol. 1997, 4, 115-117.

Triplex tethered oligonucleotide probes. A.C. Moses & A. Schepartz, J. Am. Chem. Soc. 1996, 118, 10896-10897.

Conformation of tax-response elements in the human T-cell leukemia virus type I promoter. J.M. Cox, L.S. Sloan & A. Schepartz, Chemistry & Biology 1995, 2, 819-826.

Studies on the formation of protein•DNA interfaces: DNA specificity and straightening by CREB. M.K. Hamm & A. Schepartz, Bio. Med. Chem. Lett. 1995, 5, 1621-1626.

DNA bending and binding by metallo-peptide models of bZIP proteins. C.R. Palmer, L.S. Sloan, J.C. Adrian, Jr., B. Cuenoud, D.N. Paolella & A. Schepartz, J. Am. Chem. Soc. 1995, 117, 8899-8907.

Mechanism of DNA binding enhancement by the HTLV-I transactivator tax. A.M. Baranger, C.R. Palmer, M.K. Hamm, H. A. Giebler, A. Brauweiler, J.K. Nyborg, & A. Schepartz, Nature 1995, 376, 606-608.

Convenient syntheses of reagents for cleavage mapping experiments. M. H. Hayward, J. C. Adrian, Jr. & A. Schepartz, J. Org. Chem. 1995, 60, 3924-3927.

Technical comment: Nonspecific DNA bending and the specificity of protein•DNA interactions. A. Schepartz, Science 1995, 269, 988-989.

Peptide models of bZIP proteins: Quantitative analysis of DNA affinity and specificity. S.J. Metallo & A. Schepartz, Tech. Protein Chem. 1995, VI, 385-391.

Mechanistic studies on the formation of bZIP•DNA interfaces: A simple example of supramolecular stereochemistry. D.N. Paolella, C.R. Palmer, S.J. Metallo & A. Schepartz, in Supramolecular Stereochemistry, J. Siegel, Ed. NATO Adv. Ser. 1995, 83-90.

A uniquely modified RNA: Site-specific introduction of a single RNA cleavage agent into the M1 ribozyme. P.L. Richardson, M.L. Gross, R.D. Smith, K.J. Light-Wahl, & A. Schepartz, Bio. Med. Chem. Lett. 1994, 4, 2133-2138.

Distribution of labor among CRE-BP1 bZIP segments in the control of DNA affinity and specificity. S.J. Metallo & A. Schepartz, Chem. Biol. 1994, 1, 143-152.

Mapping regions in eukaryotic ribosomes that are accessible to methidiumpropyl- EDTA•Fe(II) and EDTA•Fe(II). H. Han, A. Schepartz, M. Pelligrini & P.B. Dervan, Biochemistry 1994, 33, 9831-9844.

DNA targets for certain bZIP proteins distinguished by an intrinsic bend. D.N. Paolella, C.R. Palmer & A. Schepartz, Science 1994, 264, 1130-1133.

Selection of structure-specific inhibitors of the HIV rev–rev response element Complex. S.T. Cload & A. Schepartz, J. Am. Chem. Soc. 1994, 116, 437-443.

A kinetic and thermodynamic analysis of RNA binding by tethered oligonucleotide probes: Alternative structures and conformational changes. S.T. Cload, P.L. Richardson, Y. Huang & A. Schepartz, J. Am. Chem. Soc. 1993, 115, 5005-5014.

Altered specificity of DNA-binding proteins with transition metal dimerization domains. B. Cuenoud & A. Schepartz, Science 1993, 259, 510-513.

Design of a metallo-bZIP peptide that discriminates between CRE and AP1 target sites: Selection against AP1. B. Cuenoud & A. Schepartz, Proc. Natl. Acad. Sci. USA 1993, 90, 1154-1159.

Protein-cleavage mapping: A new tool for drug discovery and protein folding studies. M. Hayward & A. Schepartz, in Perspectives in Medicinal Chemistry, Testa, B., Kyburz, E., Fuhrer, W.; Giger, R., Eds., Verlag: Basel, 1993, p. 501-512.

Conformation-dependent cleavage of staphylococcal nuclease with a disulfide-linked iron chelate. M. Ermacora, J.M. Delfino, B. Cuenoud, A. Schepartz & R.O. Fox, Proc. Natl. Acad. Sci. USA 1992, 89, 6383-6387.

A new strategy for directed protein cleavage. B. Cuenoud, T. Tarasow & A. Schepartz, Tetrahedron Lett. 1992, 33, 895-898.

Binding of alkali cations by self-assembling ionophore complexes of Ni(II). M.W. Jones, N. Gupta, A. Schepartz & H. Thorpe, Inorg. Chem. 1992, 31, 1308-1310.

A general scheme for incorporating nonnatural functionality into peptides. B. Cuenoud & A. Schepartz, Tetrahedron Lett. 1991, 32, 3325-3328.

Polyether tethered oligonucleotide probes. S.T. Cload & A. Schepartz, J. Am. Chem. Soc. 1991, 113, 6324-6326.

Tethered oligonucleotide probes. A strategy for the recognition of structured RNA. P. Richardson & A. Schepartz, J. Am. Chem. Soc. 1991, 113, 5109-5111.

Synthesis of -BOC--EDTA-lysine tribenzyl ester. An amino acid analog suitable for solid phase peptide synthesis. B. Cuenoud & A. Schepartz, Tetrahedron 1991, 47, 2535- 2542.

Site-specific cleavage of the protein calmodulin using a trifluoperazine-based affinity reagent. A. Schepartz & B. Cuenoud, J. Am. Chem. Soc. 1990, 112, 3247-3249.

Self-assembling ionophores. A. Schepartz & J.P. McDevitt, J. Am. Chem. Soc. 1989, 111, 5976-5977.

On the mechanism of catalysis by the enzyme carboxypeptidase A. R. Breslow & A. Schepartz, Chemistry Letters 1987, 1-4.

Hydrolysis of an amide in a carboxypeptidase model using Co(III) and bifunctional catalysts. A. Schepartz & R. Breslow, J. Am. Chem. Soc. 1987, 109, 1814-1826.

Substituent effect on the electrochemical oxidation of arylmethyl anions. 3. Effect of methyl substitution on diarylmethyl anions. S. Bank, A. Schepartz, P. Giammateo, J. Zubieta, J. Org. Chem. 1983, 48, 3548-3564.